| Re-Logic | Floyds Knobs | 2011 |
| Red Wing Shoes | Red Wing | 1905 |
| Reebok | Boston | 1895 |
| Remington Arms | Madison | 1816 |
| Remo | Santa Clarita | 1957 |
| Remote Control Productions | Santa Mônica | 1989 |
| Reynolds American | Winston-Salem | 2004 |
| Royal Caribbean Group | Miami | 1997 |
| Ruger | Southport | 1949 |
| SAS | Cary | 1976 |
| Schecter Guitar Research | Los Angeles | 1976 |
| Schlumberger | Houston | 1926 |
| Seagate Technology | Cupertino | 1979 |
| Sealy Corporation | Trinity | 1881 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| Sherwin-Williams | Cleveland | 1866 |
| Siebel Systems | Austin | 1993 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| SiRF | São José | 1995 |
| Six Flags | Charlotte | 1 de julho de 2024 |
| Skechers | Manhattan Beach | 1992 |
| Smith & Wesson | Springfield | 1852 |
| Sonos | Santa Bárbara | 2002 |
| Southern Company | Atlanta | 1945 |
| Spansion | Sunnyvale | 2003 |
| Spanx | Atlanta | 2000 |
| Specialized | Morgan Hill | 1974 |
| Speedway Motorsports | Concord | 1959 |
| Staples Inc. | Framingham | 1986 |
| Starwood | White Plains | 1930 |
| Steinway Musical Instruments | Waltham | 1995 |
| Stellantis North America | Chrysler Headquarters and Technology Center | 28 de abril de 2009 |
| Stratolaunch Systems | Montgomery, Seattle | 2011 |
| Subway | Milford | 28 de agosto de 1965 |
| Sumisho Air Lease | Los Angeles | 2010 |
| Sunkist Growers | Los Angeles | 29 de agosto de 1893 |
| Sunoco | Dallas | 1886 |
| SureFire | Fountain Valley | 1979 |
| Sylvania Electric Products | — | 1942 |
| Synaptics | Santa Clara | 1986 |
| Synopsys | Mountain View | 1986 |
| Taser International | Scottsdale | setembro 1993 |
| Telltale Games | São Rafael | julho 2004 |
| Tenneco | Lake Forest | 1930 |
| TerraPower | Bellevue | 2008 |
| Texaco | San Ramon | 1901 |
| The Bank of New York Mellon | Nova Iorque | 2007 |
| The Cigna Group | Bloomfield | 1982 |