| Reebok | Boston | 1895 |
| Regent Seven Seas Cruises | Miami | 1990 |
| Remington Arms | Madison | 1816 |
| Remo | Santa Clarita | 1957 |
| Remote Control Productions | Santa Mônica | 1989 |
| Replit | São Francisco | — |
| ReverbNation | Durham | 31 de outubro de 2006 |
| Reynolds American | Winston-Salem | 2004 |
| Richard Childress Racing | — | 1969 |
| Rickenbacker | Santa Ana | 1931 |
| RKO Pictures | Manhattan | 23 de outubro de 1928 |
| Robinhood | Palo Alto | 2013 |
| Rockwell Collins | Cedar Rapids | 1933 |
| Roxio | Santa Clara | 2001 |
| Royal Caribbean Group | Miami | 1997 |
| Ruger | Southport | 1949 |
| Ryder | Coral Gables | 1933 |
| S3 Graphics | Fremont, Califórnia | janeiro 1989 |
| Saucony | Lexington | 1898 |
| Schecter Guitar Research | Los Angeles | 1976 |
| Schlumberger | Houston | 1926 |
| Scholastic Corporation | Nova Iorque, Scholastic Building | 1920 |
| Schweizer Aircraft Corporation | Horseheads, Nova Iorque | 1939 |
| Schwinn | Chicago | 1895 |
| Scribd | São Francisco | março 2006 |
| Seagate Technology | Cupertino | 1979 |
| Sealy Corporation | Trinity | 1881 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| Seattle Computer Products | Seattle | 1979 |
| Seattle's Best Coffee | Seattle | 1991 |
| Sekai Project | Norwalk, Los Angeles | 2007 |
| Semrush | Boston | 3 de agosto de 2008 |
| Seymour Duncan | Goleta | 1978 |
| Sheaffer | Shelton | 1912 |
| Shen Yun | Deerpark | 2006 |
| Sheraton Hotels & Resorts | White Plains | 1937 |
| Sherwin-Williams | Cleveland | 1866 |
| Shiny Entertainment | Laguna Beach, Newport Beach | 1993 |
| Showtime | Nova Iorque | 1983 |
| Siebel Systems | Austin | 1993 |
| Sierra Nevada Corporation | Sparks | 1963 |
| Silver Pictures | Los Angeles | 1980 |
| Similarweb | Givatayim | 2007 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| Singularity University | Mountain View | 2010 |
| SiRF | São José | 1995 |
| Sirius Satellite Radio | Nova Iorque | 17 de maio de 1990 |
| Six Flags | Charlotte | 1 de julho de 2024 |