| Skechers | Manhattan Beach | 1992 |
| Sketchfab | Nova Iorque | 2012 |
| Skullcandy | Park City | 2003 |
| Skywalker Sound | Lucas Valley | 1975 |
| Smith & Wesson | Springfield | 1852 |
| Snap Inc. | Santa Mônica, Venice | 16 de setembro de 2011 |
| Snap-on | Kenosha | 1920 |
| Snowflake Inc. | San Mateo | 2012 |
| Sociedade de Criação de Língua | Garden Grove | 2007 |
| Sonos | Santa Bárbara | 2002 |
| Sony Corporation of America | Sony Building, Nova Iorque | 1960 |
| Southern Company | Atlanta | 1945 |
| Soylent | Los Angeles | 2013 |
| SpaceX | Starbase | 14 de março de 2002 |
| Spansion | Sunnyvale | 2003 |
| Spanx | Atlanta | 2000 |
| Specialized | Morgan Hill | 1974 |
| Spectravideo | — | 1981 |
| Speedway Motorsports | Concord | 1959 |
| Sprouts Farmers Market | Phoenix | julho 2002 |
| SRI International | Menlo Park | 1946 |
| Stage 6 Films | Culver City | 2007 |
| Staples Inc. | Framingham | 1986 |
| Starwood | White Plains | 1930 |
| State Farm Insurance | Bloomington | 1922 |
| Steelcase | Grand Rapids | 1912 |
| Steinway Musical Instruments | Waltham | 1995 |
| Stellantis North America | Chrysler Headquarters and Technology Center | 28 de abril de 2009 |
| Stratolaunch Systems | Montgomery, Seattle | 2011 |
| Stripe | São Francisco, South San Francisco | 2010 |
| Studebaker | South Bend | 1852 |
| SugarCRM | Cupertino | 2004 |
| Sumisho Air Lease | Los Angeles | 2010 |
| Sunkist Growers | Los Angeles | 29 de agosto de 1893 |
| Sunoco | Dallas | 1886 |
| SunPower | São José | 1985 |
| SureFire | Fountain Valley | 1979 |
| SurveyMonkey | San Mateo | 1999 |
| Synaptics | Santa Clara | 1986 |
| Synopsys | Mountain View | 1986 |
| System 76 | Denver | 7 de novembro de 2005 |
| Tandem Computers | Cupertino | 1974 |
| Taser International | Scottsdale | setembro 1993 |
| TaylorMade Golf Company | Carlsbad | 1979 |
| Tazo | Portland | 1994 |
| TBWA Worldwide | Nova Iorque | 1970 |
| Teledyne Technologies | Thousand Oaks | 1960 |
| Telltale Games | São Rafael | julho 2004 |