| Crosley | Cincinnati | 1937 |
| Crystal Cruises | Los Angeles | 1988 |
| Culligan | Rosemont | 1936 |
| Currier and Ives | Nova Iorque | 1835 |
| Cushman & Wakefield | Nova Iorque | 1917 |
| Cypress Semiconductor | São José | 1982 |
| Cyrix | Richardson | 1988 |
| Databricks | São Francisco | 2013 |
| Datapoint | — | 1968 |
| DataStax | Santa Clara | abril 2010 |
| DC Universe | Burbank | 2018 |
| Dean Foods | Dallas | 1925 |
| Dean Guitars | Tampa | 1976 |
| Deckers Outdoor Corporation | Goleta | 1973 |
| Deere & Company | Moline | 1868 |
| Dell | Round Rock | 7 de setembro de 2016 |
| Dell Technologies | Round Rock | 7 de setembro de 2016 |
| Delta Air Lines | Atlanta | 17 de junho de 1929 |
| Detroit Electric Car Company | Detroit | 1907 |
| Devon Energy | Oklahoma City | 1971 |
| Diamond-Star Motors | — | outubro 1985 |
| Digital Eclipse | Califórnia | 7 de agosto de 1992 |
| Digital Realty | Austin | 2004 |
| DigitalOcean | Nova Iorque | agosto 2011 |
| Diller Scofidio + Renfro | — | 1981 |
| Dimensional Fund Advisors | Austin | 1981 |
| Discovery Communications | Nova Iorque | 1982 |
| Disney Interactive Media Group | Glendale | 1994 |
| Disney Television Animation | Glendale | 5 de dezembro de 1984 |
| Doble steam car | Detroit, Waltham | 1909 |
| Docusign | São Francisco | 2003 |
| Dodge & Cox | São Francisco | 1930 |
| Dollar Tree | Chesapeake | 1986 |
| Domino's Pizza | Domino's Farms, Ann Arbor Charter Township | 1960 |
| DoubleTree by Hilton | McLean | 1969 |
| Dow Jones & Company | Nova Iorque | 1882 |
| Dr Pepper Snapple Group | Plano | 7 de maio de 2008 |
| Dr. Scholl's | Chicago, Londres | 1906 |
| Draken International | Lakeland | janeiro 2012 |
| Duke Energy | Charlotte | 1997 |
| Dune Entertainment | Los Angeles | 2006 |
| Dunkin' Donuts | Canton, Quincy | 1950 |
| DuPont | Wilmington | 19 de julho de 1802 |
| DXC Technology | Tysons Corner | 3 de abril de 2017 |
| Dynetics | Huntsville | 1974 |
| E-mu Systems | Scotts Valley | 1971 |
| E-ZPass | Wilmington | 1987 |
| EA Sports | Burnaby | 1991 |