| EarthLink | Atlanta, Pasadena, Atwater Village | 1994 |
| Eastman Kodak | Rochester, Nova Iorque | 1882 |
| EBay | São José | 3 de setembro de 1995 |
| EBSCO Information Services | Birmingham | 1943 |
| EchoStar | Englewood | 1980 |
| Eckō Unlimited | East Brunswick | 1993 |
| Edison International | Rosemead | 1886 |
| Eldeman | Nova Iorque | 1952 |
| Elevance Health | Indianápolis | 2004 |
| EMachines | Irvine | setembro 1998 |
| Embarcadero Technologies | Austin | outubro 1993 |
| Emerson Electric | St. Louis | 24 de setembro de 1890 |
| EMG | Santa Rosa | 1976 |
| Energizer | St. Louis | 2000 |
| Energy Transfer | Dallas | 1996 |
| Ensoniq | Malvern | 1982 |
| Enstrom Helicopter Corporation | Menominee | 1959 |
| Enterprise Products | Houston | 1968 |
| Epicor | Austin, Irvine | 1972 |
| Epyx | São Francisco | 1978 |
| Equinix | Redwood City | 22 de junho de 1998 |
| Estée Lauder Companies | Neuilly-sur-Seine, Nova Iorque | 1946 |
| Estúdios Keystone | Edendale | 1912 |
| Etsy | Dumbo, Nova Iorque, Brooklyn | 18 de junho de 2005 |
| Everlast | Nova Iorque | 1910 |
| Exelon | Chicago | 2000 |
| Exidy | Sunnyvale | 1974 |
| Expand Energy | Oklahoma City | 1989 |
| Expedia | Seattle | 22 de outubro de 1996 |
| Extreme Championship Wrestling | Filadélfia | 25 de abril de 1992 |
| Exxon | Las Colinas | 1 de janeiro de 1973 |
| ExxonMobil | Spring | 5 de agosto de 1882 |
| FactSet | Norwalk | 1978 |
| Fageol | Oakland | 1916 |
| Fairmont Hotels & Resorts | Toronto | 1907 |
| Fandango (empresa) | Los Angeles | 2000 |
| Farmers Insurance Group | Wilshire Boulevard, Los Angeles | 1928 |
| Federal Home Loan Banks | Boston, Chicago, Pittsburgh, Dallas, Atlanta, Des Moines, Topeka, Cincinnati, Nova Iorque, São Francisco, Indianápolis | 1932 |
| FEI Company | Hillsboro | 1971 |
| Fenty Beauty | 425 Market Street | 8 de setembro de 2018 |
| Fenway Sports Group | Boston | 2001 |
| Fidelity National Information Services | — | 1 de fevereiro de 2006 |
| Firebase | São Francisco | 2010 |
| Firehouse Subs | — | 1994 |
| FirstEnergy | Akron | 1997 |
| Fitbit | São Francisco | 2007 |
| Flex LTD | São José, Singapura | 1969 |
| FMC Corporation | Mellon Bank Center | 1883 |